Antibody Discovery
Don’t let your best cell go undiscovered.
Traditional screening misses more than it finds. Our platforms let you screen up to 40 million cells in a day — without compromising viability.
More cells. More chances. Better antibodies.
Does the portion of your sample you haven’t screened keep you up at night, wondering if you might have missed optimal cells? Frustrated with inefficient methods and multiple instruments? Eliminate bottlenecks and accelerate your research with our all-in-one platforms.
Don’t be left wondering what you might have missed.
Effortlessly screen, isolate, and image cells to find high-value antibodies. Our platforms combine screening, isolation, and imaging to save time and let you find the cells you want – fast.
- Fully integrated workflow to find the cells you want
- Sensitive single cell assays to assess antibody expression
- Select and dispense single cells directly into microwell plates
- Rapidly screen large populations of B-cells or hybridomas
Optimized for antibody applications
High performance assays
FRET-based assays for antibody secretion
Our FRET-based assays let you measure antibody secretion accurately at the single cell level and thus make robust selection of high-value cells. FRET (Foster Resonance Energy Transfer) uses two probes, one targeted to the Fc region and one to the antigen-specific region, each labelled with a fluorophore. In the presence of the antibody, the two probes bind bringing the fluorophores close so laser excitation of the donor fluor results in resonance that excites the acceptor probe.
Cell-friendly processing
Cells thrive in picodroplets
Picodroplets provide a uniquely protective environment to maintain cell viability during incubation and sorting, even when moving at high speeds through microfluidic channels. Our biocompatible surfactants used to make droplets allow high rates of gas exchange to improve post-sorting cell outgrowth.
Rapid, accurate screening
Screening at unprecedented speed and scale
Large populations are no longer a problem. Screen millions of cells for antigen-specific antibody secretion in a day: with literally every single cell individually assessed and characterized.
Simplified workflows
Multiple instruments in one platform
All the process steps you need in one platform: cell encapsulation with assay reagents, incubation, secretion assessment, cell selection, monoclonality check, and dispensing into microwell plates all in one – all completely hands-off along with all supporting data. Each run uses a disposable cartridge to eliminate any cleaning or concerns about cross-contamination between runs.
Built on picodroplet technology
At the heart of our platforms are picodroplets – picolitre-volume aqueous droplets in a carrier oil. Each droplet acts as a tiny separate test tube. Cells are encapsulated in droplets with the assay reagents and passed through microfluidics for sorting and dispensing. Miniaturized, high-speed and fully automated to streamline your application.
The Next Generation: Cyto-Mine® Chroma
Automate. Accelerate. Analyze millions of cells in a single day.
Think Cyto-Mine®, but supercharged, enabling multiplexing and greater assay flexibility to fit your needs. It means that you can examine vastly greater numbers of cells — and isolate the most valuable ones— with unparalleled precision.
What our customers are saying
“Single-cell analysis allows detection of those very rare antibodies or potential drugs with unique properties that are exceptionally hard to find. My experience in drug discovery since the early 1990s all points to the importance of diversity, and Cyto-Mine® is well-placed to explore this effectively. This technology takes screening capability, traditionally conducted through plate-based analysis, to a whole new level via continuous flow. There is huge potential for the instrument in discovering the rarest cells and best antibodies”
Dr Tristan Vaughan
Antibody & Protein Engineer Executive
We’re the droplet microfluidic technology company for single-cell analysis and our customers are at the center of what we do.
Our integrated,
automated platforms
increase efficiency,
delivering value.
Our unmatched
picodroplet technology
is future proof
Our platform is built upon robust evidence from key opinion leaders
Our collaboration with customers is
second to none
Have a question for us?
Our team of experts are on hand to provide you with the information and support you need. Whether you have a question about our products, services or training, we're always happy to assist you
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