Microfluidics-Enabled Antibody Discovery: Expediting Cancer and Immunology Research
Summary of Recent Advances in Microfluidic-Assisted Antibody Screening
Discover how Cyto-Mine® technology by Sphere Bio enhances antibody discovery with speed and precision. This 2021 study, published in mAbs, highlights how our microfluidics technology supports a “function first” screening approach of antibody-secreting cells, providing rapid identification of therapeutic candidates in just weeks.
Research highlights
- Study Title: Versatile and Rapid Microfluidics-Assisted Antibody Discovery
- Authors: Ramona Gaa, Emmanuel Menang-Ndi, Shruti Pratapa, Christine Nguyen, Satyendra Kumar, Achim Doerner
- Published In: mAbs Journal, 2021
- DOI: 10.1080/19420862.2021.1978130
Key findings
High Throughput and Precision: By using Cyto-Mine® technology, researchers screened up to two million droplets (1 million cells), identifying viable antibody-secreting cells with great efficiency with shortened timelines.
Functional Screening: This method supports functional IgG antibody screening, internalization and intracellular signaling, virus neutralization and the identification of cancer and immune disease antibodies with improved speed.
Antibody Development in Record Time: The Cyto-Mine® process—from cell preparation to antibody confirmation—was completed in four weeks, highlighting its ability to condense and streamline the antibody discovery process.
Additional Highlights
Streamlined Workflow: Microfluidics allows efficient screening for functionality in droplets, making Cyto-Mine® technology ideal for labs focusing on immune and cancer therapeutics.
Innovative Screening Capabilities: Researchers demonstrated functional antibody screening, which could support the development of therapeutic antibodies for diseases that are difficult to treat, including cancer and autoimmune diseases.
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Cyto-Mine® Chroma
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