Cell Engineering
Innovate Your Cell Engineering with Precision Picodroplet Technology
Transform cell engineering with our state-of-the-art platforms. Experience unparalleled control and efficiency in transduction, transfection, and post-modification sorting, all within stable, high-speed Picodroplets.
Gene editing in picodroplets
It’s not just sorting and dispensing. Picodroplets are ultra-miniature reaction vessels and can be used to engineer cells – individually. Talk to our applications support team to discuss how our technology could work for your projects.
- Engineering mammalian cells
- Transduction and transfection
- Effortless selection and sorting post-modification
Built on picodroplet technology
At the heart of our platforms are picodroplets – picolitre-volume aqueous droplets in a carrier oil. Each droplet acts as a tiny separate test tube. Cells are encapsulated in droplets with the assay reagents and passed through microfluidics for sorting and dispensing. Miniaturized, high-speed and fully automated to streamline your application.
Engineering cells individually
Droplet stability
Picodroplets support your workflow
Cell engineering workflows can take time – often days to execute. Picodroplets remain stable for these extended periods and allow high rates of gas transfer to maintain long-term cell viability, up to 72 hours from encapsulation.
Transduction and transfection
Picodroplets support either approach
We have implemented workflows for both transduction and chemical transfection. We demonstrated successful editing using baculovirus, with 35% of all cells showing outgrowth and 3% with successful editing events. We also demonstrated CRISPR-RNP editing using chemical transfection, with 20% of cells edited and 16% showing outgrowth.
Validated on multiple cell types
A widely-applicable technology
Picodroplets work with multiple cell types: Murine neural stem cells, Suspension cells – CHO, Jurkat, THP1, RAJI, Adherent cells – HCT116, A431, A549, HEK293.
Integrated workflows
Engineer, characterize and select
Your entire workflow can be run within picodroplets. Engineer your cells, assay them to identify successful editing, select the good ones, and dispense them into plates for subsequent outgrowth. Automated, robust and easy to use to free up your time and mental capacity.
What our customers are saying
“Single cell analysis allows detection of those very rare antibodies or potential drugs with unique properties that are exceptionally hard to find. My experience in drug discovery since the early 1990s all points to the importance of diversity, and Cyto-Mine® is well-placed to explore this effectively. This technology takes screening capability, traditionally conducted through plate-based analysis, to a whole new level via continuous flow. There is huge potential for the instrument in discovering the rarest cells and best antibodies”
Dr Tristan Vaughan
Antibody & Protein Engineer Executive
The Next Generation: Cyto-Mine® Chroma
Automate. Accelerate. Analyze millions of cells in a single day.
Think Cyto-Mine®, but supercharged, enabling multiplexing and greater assay flexibility to fit your needs. It means that you can examine vastly greater numbers of cells — and isolate the most valuable ones— with unparalleled precision.
We’re the droplet microfluidic technology company for single-cell analysis and our customers are at the center of what we do.
Our integrated,
automated platforms
increase efficiency,
delivering value.
Our unmatched
picodroplet technology
is future proof
Our platform is built upon robust evidence from key opinion leaders
Our collaboration with customers is
second to none
Have a question for us?
Our team of experts are on hand to provide you with the information and support you need. Whether you have a question about our products, services or training, we're always happy to assist you
Contact us
