We’re proud to be attending SLAS Europe 2025 Conference and Exhibition, which will bring together the European life sciences and laboratory technology community in Hamburg, Germany, from 20-22 May. This year’s program will showcase cutting-edge advancements in drug discovery, laboratory automation, and screening applications, offering a unique opportunity to explore the latest technologies shaping the future of research.
Don’t miss your chance to be part of the conversations shaping the future of life sciences – register today and join us in Hamburg!
POSTER PRESENTATION
Poster Session A
Curtis Nicholson
Executive Director – Strategic Accounts
Sphere Bio
Abstract
Antibody therapeutics dominate drug development; however, lengthy workflows and rising costs in their discovery and development present significant challenges.
Sphere Bio’s Cyto-Mine® system leverages picodroplet technology, microfluidics, and imaging to overcome these hurdles in Antibody Discovery (AbD) and Cell Line Development (CLD), accelerating therapeutic development.
Here we introduce the next-generation Cyto-Mine platform, Cyto-Mine Chroma. This advanced microfluidic platform, equipped with multi-laser, single-cell analysis capabilities, enables high-throughput, multiplex functional screening of millions of cells in a single day. Our findings demonstrate that Cyto-Mine Chroma can precisely sort and dispense cells based on fluorescence signals and sequential gating.
Additionally, it achieves over 90% accuracy in isolating cells based on productivity and membrane dye from mixed populations. In an experiment simulating an AbD workflow, Cyto-Mine Chroma successfully isolated rare cells secreting antigen-specific antibodies with high precision. Furthermore, by utilizing a viability dye alongside IgG-specific probes, we demonstrated its ability to isolate CHO cells producing human IgG4 based on both productivity and viability, without compromising cell performance.
These results highlight Cyto-Mine Chroma’s robust multiplexing capabilities, making it an invaluable tool for isolating specific cell populations in both CLD and AbD workflows.
