Cyto-Mine® selected by FairJourney Biologics to advance cell line development workflows

Cambridge, UK, and Porto, Portugal [03 October 2023]: Sphere Bio, a company developing single cell analysis systems underpinned by its patented picodroplet technology, today announced the Cyto-Mine^® platform has been selected by FairJourney Biologics, a world leading end-to-end antibody partner, providing integrated services across antibody discovery, engineering, and production, to expand its cell line development capabilities. FairJourney Biologics has adopted the platform as part of the launch for its latest cell line development services, to streamline and accelerate customer workflows.

FairJourney Biologics’ team of experts comprises an extensive knowledge of cellular biology, enabling them to tailor cell lines precisely to their partners’ unique requirements. Leveraging state-of-the-art technologies and meticulous quality control measures, FairJourney Biologics consistently delivers high-performing, stable cell lines that serve as the foundation for efficient antibody production and therapeutics development. Cyto-Mine^® ‘s advanced features, such as selection of producer clones, monoclonality assurance, significant time savings, flexible assay designs, GLP compliance support, and regulatory compatibility, seamlessly complement FairJourney Biologics’ services, providing partners with comprehensive and efficient solutions for their research and development endeavors.

Traditional processes for finding novel antibody targets or developing stable cell lines are typically time-consuming, often inefficient, and difficult to scale. Cyto-Mine^® is an automated platform which integrates single cell screening, sorting, dispensing, imaging, and clone verification, with proof of monoclonality. Underpinned by Sphere Bio’s patented, microfluidic picodroplet technology, it provides an integrated system with an easy-to-use and intuitive interface that can automatically, yet gently, screen up to 40 million cells in a matter of hours, compared with 10,000 typically achieved using multi-step manual techniques. This accelerated throughput is already widely recognized across a variety of research areas, including antibody discovery, cell line development, cell engineering and synthetic biology. The platform also facilitates rapid, high-throughput single cell manipulation and analysis across an expanding range of emerging research areas, including precision genome editing, cell therapy research and cellular diagnostics.

FairJourney Biologics’ partners will also benefit from the Cyto-Mine^®’s recent software updates, supporting FDA 21 CFR Part 11 compliance and including a full Installation Qualification / Operation Qualification (IQ/OQ) package for pharmaceutical quality assurance, extending the system’s applications into drug manufacturing operations.